The Hematopoietic Stem Cells of a - Thalassemic Mice
نویسندگان
چکیده
The a-thalassemic mouse has a hereditary microcytic anemia. almost certainly has a shortened RBC life span. and is a potential candidate for cell replacement therapy. In a routine study of bone marrow repopulating capacity using hemoglobin as a cell marker. normal donor marrow cells. but not a-thalassemic donor marrow cells. completely replaced the host cells. Further analysis showed that at least 30 times more a-thalassemic cells were required to outcompete normal donor cells injected simultaneously. The results were more extreme then expected and suggested a defect in a stem cell population as well as in the RBCs. Evidence that the multipotent and erythroid-
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